If pleasure were itself sacred, then the negating of sacredness (profaning) would also negate the pleasure itself.

In a way, that is actually what happens. People who are sexually abused, or who are addicted for a long time to pleasure-giving substances, find it difficult to feel or experience pleasure, either because it becomes tied in with negative feelings that negate it, or because the brain becomes endorphin-deficient -- which explains why some people with severe post-traumatic stress disorder are frequently addicted to drugs or alcohol.